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Upon binding to IL12R, the JAK2 was linked to IL12R2, and then STAT4 was phosphorylated, after which the dimerized STAT4 could be transferred to the nucleus to alter gene expression (48, 49)

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20 Globally, breast cancer accounts for roughly one-third of all malignancies in women, with its mortality rate constituting about 15% of the total number of cases diagnosed